Formaldehyde releaser
Formaldehyde-releasing urinary antiseptic
- Nonspecific antimicrobial denaturation
- Suppression of recurrent UTI, not acute infection
- Requires acidic urine — fails with urease-producing organisms (Proteus)
- No acquired bacterial resistance
- Releases formaldehyde in acidic urine — urinary antisepsis
- Requires acidic urine to work
Drugs with this mechanism (2)
- Methenamine hippurate — Urinary antiseptic that releases formaldehyde in acidic urine.
- Methenamine mandelate — Urinary antiseptic releasing formaldehyde in acidic urine.
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