ERβ agonist
Estrogen receptor beta (ERβ) agonist
- Classic nuclear receptor
- Typically acts as a modulator or counterbalance to ERα stimulation
- Antiproliferative, anti-inflammatory, neuroprotective
- Classic nuclear receptor
- Typically acts as a modulator or counterbalance to ERα stimulation
- Antiproliferative, anti-inflammatory, neuroprotective
Drugs with this mechanism (7)
- Conjugated estrogens — Estrogen mixture for menopausal symptoms.
- Estradiol — Principal human estrogen; available systemically or locally for menopausal symptoms.
- Estradiol transdermal — Skin-delivered estrogen for menopausal symptoms; avoids first-pass hepatic exposure.
- Estradiol vaginal — Local estrogen for menopausal genitourinary symptoms; little systemic exposure.
- Estriol — Relatively weak estrogen prominent in pregnancy; used vaginally for menopausal symptoms in some countries, but not FDA-approved.
- Estrone — Major circulating estrogen after menopause, formed largely by peripheral aromatization; interconverts with the more potent estradiol.
- Ethinyl estradiol — The synthetic estrogen in most combined oral contraceptives.
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