SSADH inhibitor
Succinic semialdehyde dehydrogenase inhibitor
- ↓ GABA degradation
- Raises brain GABA
- Works with GABA-transaminase inhibition toward the same end
- ↑ GHB from accumulated succinic semialdehyde
- Blocks GABA breakdown, raising brain GABA
Drugs with this mechanism (5)
- Valproic acid — Broad-spectrum anticonvulsant and mood stabilizer; highly teratogenic and metabolically burdensome.
- Divalproex DR — Delayed-release broad-spectrum antiseizure drug and mood stabilizer; highly teratogenic.
- Divalproex ER — Extended-release broad-spectrum antiseizure drug and mood stabilizer; highly teratogenic.
- Valproate sodium IV — Intravenous valproate for seizures when oral therapy is unavailable; broad-spectrum but highly teratogenic.
- Divalproex sprinkle — Valproate sprinkle capsule for seizures; useful when intact tablets cannot be swallowed.
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