CB2 agonist
CB2 cannabinoid receptor agonist
- Immune-cell CB2 → reduces inflammation
- CB2 does not mediate the cannabis high — that is CB1
- CB-2 does not mediate intoxication
- ↓ inflammation
- May reduce inflammation
Drugs with this mechanism (3)
- 2-Arachidonoylglycerol — The most abundant endocannabinoid and a full CB1 agonist, made on demand by the postsynaptic neuron.
- JWH-018 — A synthetic cannabinoid ("Spice"); a full CB1 agonist, unlike THC.
- Nabilone — Synthetic CB1 agonist for chemotherapy nausea refractory to standard antiemetics.
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