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JWH-018

synth. cannab.

JWH-018 ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: JWH-018 ballicule

What it isSynthetic cannabinoid and full CB1 agonist; illicit "spice" products.

Why this oneFull agonism, unlike THC’s partial agonism, is why the toxicity is disproportionate.

What limits itSeizures, psychosis and death, none of which occur with cannabis. It is not detected on routine cannabinoid screens.

JWH-018 molecular structure (skeletal formula)
Molecular structure: JWH-018

FDA-approved for

NO BOXED WARNINGS

Principal riskSeizures, psychosis and death, none of which occur with cannabis

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

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