CB1 agonist
CB1 cannabinoid receptor agonist
- Euphoria, analgesia, appetite stimulation, antiemetic effect
- Short-term memory and motor impairment
- Anxiolytic at low dose, anxiogenic at high dose
- Psychosis risk, dose-dependent
CB1 agonist (1/2)
- Euphoria
- Analgesia
- Motor impairment
- ➔ driving risk
- Short-term memory impairment
- ↑ appetite
- Antiemetic
- Tachycardia
- Low dose → anxiolytic
CB1 agonist (2/2)
- High dose → anxiogenic
- Tolerance / dependence
- Red eyes via vasodilation
- Psychosis (dose-dependent)
- Schizophrenia risk (adolescents)
- Schizophrenia risk (adolescents) CB1
Drugs with this mechanism (3)
- 2-Arachidonoylglycerol — The most abundant endocannabinoid and a full CB1 agonist, made on demand by the postsynaptic neuron.
- JWH-018 — A synthetic cannabinoid ("Spice"); a full CB1 agonist, unlike THC.
- Nabilone — Synthetic CB1 agonist for chemotherapy nausea refractory to standard antiemetics.
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