T-type CCB
T-type calcium channel blocker
- Blocks T-type Ca²⁺ channels in thalamic relay neurons
- Suppresses the burst firing behind 3-Hz spike-wave absence seizures
- Antiepileptic drugs
- ➔ cannabidiol CCB
Drugs with this mechanism (9)
- Cannabidiol — Purified, nonintoxicating cannabinoid for severe developmental epilepsies.
- Ethosuximide — T-type calcium-channel blocker and drug of choice for pure absence seizures.
- N-desmethylmethsuximide — Active metabolite of methsuximide; the long half-life that does the work.
- Valproic acid — Broad-spectrum anticonvulsant and mood stabilizer; highly teratogenic and metabolically burdensome.
- Divalproex DR — Delayed-release broad-spectrum antiseizure drug and mood stabilizer; highly teratogenic.
- Divalproex ER — Extended-release broad-spectrum antiseizure drug and mood stabilizer; highly teratogenic.
- Valproate sodium IV — Intravenous valproate for seizures when oral therapy is unavailable; broad-spectrum but highly teratogenic.
- Divalproex sprinkle — Valproate sprinkle capsule for seizures; useful when intact tablets cannot be swallowed.
- Zonisamide — Broad anticonvulsant associated with weight loss.
All mechanisms · Open CaV T-type blocker in the interactive console ↗