AT1 antagonist
AT1 angiotensin receptor antagonist
- Vasodilation and ↓ aldosterone
- ↓ blood pressure and sodium retention
- Renal protection in diabetes
- No bradykinin cough (unlike ACE inhibitors)
- Hyperkalemia and teratogenicity remain
- Blocks angiotensin II — vasodilation and reduced blood pressure
- Renal protection in diabetes and heart failure
- Hyperkalemia; contraindicated in pregnancy
Drugs with this mechanism (10)
- Azilsartan — Potent, long-acting ARB for hypertension; often lowers pressure more than older sartans.
- Candesartan — ARB antihypertensive; also used for migraine prevention.
- Eprosartan — ARB antihypertensive.
- EXP3174 (E-3174) — Losartan's major active metabolite; a more potent, insurmountable AT1 antagonist (CYP2C9/3A4).
- Irbesartan — ARB antihypertensive with renal-protective data.
- Losartan — The first ARB; also lowers uric acid.
- Olmesartan — ARB antihypertensive; rare sprue-like enteropathy.
- Sparsentan — Dual endothelin ETA and AT1 antagonist for IgA nephropathy; hepatotoxicity and fetal toxicity REMS.
- Telmisartan — The longest-acting ARB; also a partial PPAR-gamma agonist.
- Valsartan — A widely used ARB with strong heart-failure data.
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