Eprosartan

TEVETEN

Pronunciation: ep-roe-SAR-tan

What it isAngiotensin II receptor blocker; hypertension.

Why this oneIt also blocks presynaptic AT1 receptors, giving some sympathoinhibition the other ARBs lack.

What limits itWeaker blood-pressure effect than the newer ARBs. Contraindicated in pregnancy.

FDA-approved for

⚠ BOXED WARNING

Principal riskWeaker blood-pressure effect than the newer ARBs

Therapeutic safety burden2 / 4

Overdose danger2 / 4

Weight-gain liability0 / 4

Sedation liability1 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk4 / 4

Legacy pregnancy categoryD

Defining liabilityFetal renal toxicity, hyperkalemia and renal dysfunction