Dextroamphetamine oral solution

FDA label

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Titration Increase at weekly intervals.

Renal Undefined

Hepatic Undefined

Instructions

• Administer at lowest effective dosage; give first dose on awakening, additional 1–2 doses at 4–6 hr intervals
• Avoid late-evening doses (insomnia)
• Interrupt therapy occasionally to assess need for continued treatment
• Not recommended in children under 3 years for ADHD

Available strengths

• sol 5 mg/5 mL
• tab 2.5, 5, 7.5, 10, 15, 20, 30 mg
• ER cap 5, 10, 15 mg
• patch 4.5, 9, 13.5, 18 mg/9 hr

Contraindications

• Use during or within 14 days of a monoamine oxidase inhibitor (MAOI) — hypertensive crisis may result

Cautions

• Avoid in serious cardiac disease (structural cardiac abnormalities, cardiomyopathy, serious arrhythmia, CAD) — sudden death reported
• Increases blood pressure and heart rate — monitor
• Psychiatric reactions: may exacerbate psychosis, induce mania in bipolar disorder, or cause new psychotic/manic symptoms
• Long-term growth suppression in pediatric patients — monitor height/weight
• May lower seizure threshold
• Peripheral vasculopathy, including Raynaud's phenomenon
• Serotonin syndrome with serotonergic drugs or CYP2D6 inhibitors
• Motor and verbal tics; worsening of Tourette's syndrome

Adverse reactions

• Palpitations, tachycardia, elevated blood pressure
• Overstimulation, restlessness, insomnia, dizziness, euphoria, dyskinesia, tremor, headache
• Dry mouth, unpleasant taste, diarrhea, constipation; anorexia and weight loss
• Impotence, changes in libido
• Urticaria; rhabdomyolysis

Pregnancy Pregnancy Category C; embryotoxic/teratogenic in animals; use only if benefit justifies risk. Infants of dependent mothers risk prematurity, low birth weight, and withdrawal.

Lactation Amphetamines are excreted in human milk; mothers should refrain from nursing.