Xanthine oxidase inhibitor
- ↓ uric-acid production
- Urate-lowering prophylaxis in gout
- Also blocks thiopurine breakdown — reduce thiopurine doses or risk severe toxicity
- Blocks xanthine oxidase → ↓ uric-acid production
- Also blocks thiopurine breakdown → major toxicity risk unless thiopurine dose is reduced
Drugs with this mechanism (2)
- Allopurinol — Xanthine oxidase inhibitor; first-line urate-lowering for gout prevention.
- Febuxostat — Non-purine xanthine oxidase inhibitor for gout; cardiovascular caution.
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