V2 vasopressin antagonist
- Free-water excretion without sodium loss
- Raises serum sodium in hypervolemic/euvolemic hyponatremia
- Too-rapid correction → osmotic demyelination
- Polyuria, thirst
- Conivaptan (V1, V2) and tolvaptan (V2-selective) for treatment of hyponatremia -”vaptan” = vasopressin antagonist
Drugs with this mechanism (2)
- Conivaptan — IV vasopressin antagonist (vaptan) for hyponatremia.
- Tolvaptan — Vasopressin V2 antagonist for hyponatremia and autosomal dominant polycystic kidney disease.
All mechanisms · Open Vasopressin V2 receptor antagonist in the interactive console ↗