V2 agonist
V2 vasopressin receptor agonist
- Renal aquaporin insertion → free-water retention
- Treats central diabetes insipidus and nocturnal enuresis
- Excess antidiuresis → hyponatremia
- Endothelial V2 → ↑ von Willebrand factor and factor VIII release
- In kidney → aquaporin-2 insertion (collecting duct)
- ➔ antidiuresis (water retention)
- ➔ hyponatremia
- ➔ central diabetes insipidus (replacing missing ADH)
- ➔ nocturnal enuresis
- ➔ hemophilia A
- ➔ von Willebrand Disease Type
- ➔ urgent reversal of platelet dysfunction
Drugs with this mechanism (3)
- Desmopressin — Vasopressin V2 analog for diabetes insipidus, enuresis, and bleeding.
- Terlipressin — Vasopressin analog for hepatorenal syndrome; respiratory failure limits use.
- Vasopressin — Antidiuretic hormone; a vasopressor in shock and treatment for diabetes insipidus.
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