TYK2 inhibitor
- ↓ IL-23 and type-I interferon signaling → ↓ psoriasis
- Spares JAK1/JAK2
- Blocks IL-23 and type I interferon signaling — psoriasis
- Allosteric selectivity spares JAK1 and JAK2
The JAK family at a glance
Four kinases, paired on cytokine receptors
- JAK1 + JAK3 — γ-common-chain cytokines (IL-2, -4, -7, -9, -15, -21)
- JAK2 + JAK2 — EPO, TPO, GH, GM-CSF
- JAK1 + TYK2 — type I interferons; JAK2 + TYK2 — IL-12, IL-23
Open the JAK inhibitors presentation →
Drugs with this mechanism (1)
- Deucravacitinib — Selective allosteric TYK2 inhibitor for plaque psoriasis; lacks the JAK class boxed warning.
All mechanisms · Open TYK2 inhibitor in the interactive console ↗