TTR stabilizer
Transthyretin (TTR) tetramer stabilizer
- Prevents tetramer dissociation into amyloid
- Slows ATTR cardiomyopathy and polyneuropathy
- Stabilizes existing protein rather than reducing its production
- Stabilizes transthyretin tetramers → prevents dissociation/misfolding into amyloid
Drugs with this mechanism (2)
- Acoramidis — Oral transthyretin stabilizer that holds the TTR tetramer together in ATTR cardiomyopathy.
- Tafamidis — Stabilizes the transthyretin tetramer in ATTR cardiomyopathy.
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