TRPM8 agonist
TRPM8 cold-receptor agonist
- Ocular activation stimulates tear production → treats dry-eye disease
- The receptor menthol also activates — the “cooling” sensation
- Activates the cold-sensing receptor
- Stimulates tear production in dry eye
Drugs with this mechanism (1)
- Acoltremon — TRPM8 "cold receptor" agonist eye drop that triggers the eye’s own tear reflex.
All mechanisms · Open TRPM8 agonist in the interactive console ↗