TPP cofactor: transketolase
- Connects the pentose phosphate pathway to glycolysis
- Erythrocyte transketolase activity is the classic thiamine-status assay
- Pentose phosphate pathway crosslinks — transketolase moves 2-carbon units
- Erythrocyte transketolase activity is the classic functional ASSAY for thiamine status
Drugs with this mechanism (1)
- Thiamine pyrophosphate — Active thiamine coenzyme required for carbohydrate metabolism; deficiency impairs energy production and contributes to Wernicke encephalopathy.
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