TPP cofactor: alpha-ketoglutarate dehydrogenase
- A rate step within the TCA (tricarboxylic acid) cycle
- Impaired in thiamine (B1) deficiency
- Same decarboxylation chemistry, applied inside the TCA cycle at alpha-KG → succinyl-CoA
- A second TCA choke point in thiamine deficiency — energy failure compounds
Drugs with this mechanism (1)
- Thiamine pyrophosphate — Active thiamine coenzyme required for carbohydrate metabolism; deficiency impairs energy production and contributes to Wernicke encephalopathy.
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