Direct thrombin inhibitor
- No fibrin formation or platelet activation
- Anticoagulation, including in heparin-induced thrombocytopenia
- Bleeding is the direct consequence
- Direct thrombin inhibition — anticoagulation
- Bleeding risk
Drugs with this mechanism (3)
- Argatroban — Hepatically cleared IV direct thrombin inhibitor for HIT; it falsely raises the INR.
- Bivalirudin — Short-acting IV direct thrombin inhibitor used during PCI and when heparin is unsuitable.
- Dabigatran — Oral direct thrombin inhibitor anticoagulant; idarucizumab reverses it.
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