TAAR1 agonist
Trace amine-associated receptor 1 agonist
- Indirectly modulates dopamine and glutamate — a proposed antipsychotic effect WITHOUT D2 blockade
- Efficacy unproven: ulotaront’s phase 3 schizophrenia trials did not separate from placebo
- No EPS or prolactin rise
- Modulates dopamine and glutamate signaling indirectly — antipsychotic efficacy unproven (ulotaront phase 3 did not separate from placebo)
Drugs with this mechanism (3)
- Phenethylamine — Endogenous trace amine and the structural core of the amphetamines.
- Tyramine — Dietary trace amine that triggers hypertensive crisis with MAOIs.
- Ulotaront — Investigational TAAR1/5-HT1A agonist for schizophrenia without D2 blockade; phase 3 efficacy findings have been disappointing.
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