SMO antagonist
Smoothened (SMO) antagonist — hedgehog pathway
- Shuts off aberrant Hedgehog drive → ↓ basal cell carcinoma
- Muscle spasms, dysgeusia, alopecia and teratogenicity are class effects
- Blocks Smoothened, shutting down hedgehog (Hh) pathway signaling
- The Hh pathway drives basal cell carcinoma
- Class effects: muscle spasms, taste loss, alopecia; teratogenic
Drugs with this mechanism (1)
- Vismodegib — Oral Smoothened inhibitor for unresectable or metastatic basal-cell carcinoma; profoundly teratogenic.
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