Sigma-2 agonist
Sigma-2 receptor agonist
- Sigma-2 (TMEM97) regulates cholesterol and lysosomal handling
- Clinical significance remains incompletely defined
- An emerging target in oncology and neurodegeneration imaging
- σ2 activation can promote mitochondrial dysfunction, and pro-apoptotic signaling
- Potentially neurotoxic under stress conditions
Drugs with this mechanism (3)
- Haloperidol — Prototypical high-potency typical antipsychotic; potent D2 blocker, high EPS risk.
- Haloperidol decanoate LAI — First-generation D2-antagonist depot for schizophrenia maintenance; EPS burden is high.
- Haloperidol injection — Parenteral high-potency D2 antipsychotic for acute agitation; IV use magnifies QT concern.
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