sGC stimulator
Soluble guanylate cyclase stimulator
- Sensitizes the enzyme to nitric oxide and stimulates it directly — ↑ cGMP even when NO is low
- Vasodilation in pulmonary and systemic vessels
- Synergistic hypotension with nitrates and PDE5 inhibitors — never combine
- Contraindicated with nitrates and PDE5 inhibitors
Drugs with this mechanism (2)
- Riociguat — Soluble guanylate cyclase stimulator for pulmonary hypertension.
- Vericiguat — Soluble guanylate cyclase stimulator for worsening heart failure.
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