Pyridoxine sequestrant
- Functional vitamin B6 deficiency
- Peripheral neuropathy and seizure risk
- Prophylactic pyridoxine prevents it
- Binds pyridoxine, causing functional B6 deficiency
Drugs with this mechanism (3)
- Cycloserine — Second-line tuberculosis antibiotic; NMDA activity drives severe neuropsychiatric toxicity.
- Hydralazine — Direct arteriolar vasodilator; reflex tachycardia, drug-induced lupus.
- Isoniazid — First-line tuberculosis drug; hepatotoxicity and pyridoxine-responsive neuropathy shape use.
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