Methotrexate inactivation (enzymatic)
Methotrexate inactivation (glucarpidase)
- Enzyme cleaves methotrexate into inactive metabolites
- Rapidly clears toxic methotrexate levels in renal impairment
- Interferes with methotrexate assays
- Reduced-folate rescue must be timed apart
- Enzymatically cleaves methotrexate to inactive metabolites
Drugs with this mechanism (1)
- Glucarpidase — Enzyme that rapidly breaks down circulating methotrexate in delayed clearance with kidney dysfunction; does not replace leucovorin rescue.
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