Hepatic glutathione depletion
- Consumes hepatic glutathione
- Once glutathione is exhausted, the reactive metabolite attacks hepatocytes → hepatotoxicity
- Cysteine repletion restores glutathione and blocks this step
- Depletes glutathione — the acetaminophen hepatotoxicity mechanism
Drugs with this mechanism (1)
- NAPQI — Reactive acetaminophen metabolite normally detoxified by glutathione; glutathione depletion permits severe liver injury.
All mechanisms · Open Glutathione depletion in the interactive console ↗