RyR1 blocker
Ryanodine receptor 1 blocker
- ↓ sarcoplasmic calcium release in skeletal muscle
- The antidote for malignant hyperthermia
- Treats spasticity
- Muscle weakness is dose-related
- Blocks sarcoplasmic calcium release — the malignant hyperthermia antidote
- Also used for spasticity; hepatotoxicity with chronic use
Drugs with this mechanism (1)
- Dantrolene — Blocks RyR1 calcium release in skeletal muscle; the antidote for malignant hyperthermia.
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