Bacterial RNA polymerase inhibitor
- Bacterial RNA synthesis fails
- Bactericidal
- Blocks bacterial or viral RNA synthesis
Drugs with this mechanism (5)
- Fidaxomicin — Non-absorbed macrocycle for C. difficile with lower recurrence than vancomycin.
- Rifabutin — Rifamycin antibiotic; weaker enzyme induction than rifampin makes it useful in HIV.
- Rifampin — Antituberculous rifamycin; a potent CYP inducer that turns fluids orange.
- Rifapentine — Long-acting rifamycin for once-weekly TB regimens.
- Rifaximin — Non-absorbed gut antibiotic for hepatic encephalopathy and IBS-D.
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