Reverse transcriptase inhibitor
- Islatravir: a nucleoside that blocks translocation of the primer — the chain can be built but not advanced
- Long intracellular half-life; dose-dependent lymphopenia paused development at higher doses
- Blocks viral RNA to DNA transcription
- Backbone of HIV and hepatitis B therapy
Drugs with this mechanism (1)
- Islatravir — HIV nucleoside reverse-transcriptase translocation inhibitor; coformulated with doravirine for selected virologically suppressed adults.
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