Glutamate decarboxylase cofactor
- Synthesizes GABA from glutamate
- B6 deficiency lowers GABA → seizures
- Required cofactor for glutamate decarboxylase
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
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