Purine synthesis inhibitor
- Impairs lymphocyte proliferation → immunosuppression
- Myelosuppression
- Blocks de novo purine synthesis in lymphocytes
- Myelosuppression, amplified where thiopurine metabolism is impaired
Drugs with this mechanism (2)
- Azathioprine — Purine-synthesis immunosuppressant; toxicity tracks TPMT activity.
- Mercaptopurine — Active metabolite of azathioprine; TPMT and NUDT15 testing before dosing.
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