PTH receptor agonist
- Intermittent PTH-receptor stimulation favors osteoblasts → net bone formation
- Anabolic osteoporosis therapy
- Continuous exposure would instead resorb bone — the dosing schedule is the mechanism
- Transient hypercalcemia
- Intermittent dosing is anabolic to bone
- Hypercalcemia
Drugs with this mechanism (2)
- Abaloparatide — PTHrP analog that builds bone; an anabolic osteoporosis agent.
- Teriparatide — Recombinant PTH fragment; an anabolic (bone-building) osteoporosis drug.
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