Proteasome inhibitor
26S proteasome inhibitor
- Misfolded proteins accumulate
- Antibody-secreting myeloma cells are especially vulnerable → apoptosis
- Peripheral neuropathy is the signature toxicity
- Herpes zoster reactivation → antiviral prophylaxis
- Blocks protein degradation in myeloma cells
- Peripheral neuropathy is dose-limiting
Drugs with this mechanism (1)
- Bortezomib — Proteasome inhibitor; give subcutaneously to spare the nerves.
All mechanisms · Open Proteasome inhibitor in the interactive console ↗