PPAR-delta agonist
- ↑ fatty-acid oxidation and altered lipid handling
- ↓ bile acid synthesis → ↓ cholestatic liver injury
- Modulates fatty acid oxidation and lipid handling
Drugs with this mechanism (2)
- Elafibranor — Dual PPAR-alpha/delta agonist for primary biliary cholangitis after inadequate ursodiol response.
- Seladelpar — Selective PPAR-delta agonist for primary biliary cholangitis; also improves cholestatic pruritus.
All mechanisms · Open PPAR-delta agonist in the interactive console ↗