PPAR-alpha agonist
Peroxisome proliferator-activated receptor alpha agonist
- ↑ fatty-acid oxidation → lowers plasma triglycerides — the fibrate mechanism
- Lowers plasma triglycerides
- Myopathy risk when combined with a statin
Drugs with this mechanism (5)
- Elafibranor — Dual PPAR-alpha/delta agonist for primary biliary cholangitis after inadequate ursodiol response.
- Fenofibrate — PPAR-alpha fibrate; mainly lowers triglycerides.
- Gemfibrozil — Fibrate for severe hypertriglyceridemia; the wrong fibrate to combine with a statin.
- Icosapent ethyl — Purified EPA omega-3 that lowers triglycerides and cardiovascular events.
- Omega-3 fatty acids — Mixed EPA/DHA lowers triglycerides but can raise LDL; OTC products are not equivalent.
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