PLP cofactor
Pyridoxal phosphate cofactor
- The active vitamin B6 cofactor
- Required for amino-acid decarboxylation/transamination and neurotransmitter synthesis
- The form given for isoniazid overdose seizures when the kinase step is blocked
- The active vitamin B6 form, cofactor for many enzymes
Drugs with this mechanism (1)
- Pyridoxal-5'-phosphate — The active B6 cofactor itself, for pyridoxine-unresponsive PLP-dependent epilepsy.
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