PKC inhibitor
Protein kinase C (PKC) inhibitor
- A hypothesized antimanic mechanism — not established
- Hypothesized antimanic effect — the proposed basis for tamoxifen/endoxifen benefit in mania
Drugs with this mechanism (2)
- Endoxifen — Tamoxifen's potent active metabolite — made by CYP2D6, which is why 2D6 inhibitors matter in breast cancer.
- Tamoxifen — The classic breast-cancer SERM; a prodrug activated by CYP2D6.
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