PDE5 inhibitor
Phosphodiesterase-5 inhibitor
- cGMP persists → smooth-muscle relaxation
- Erectile function and pulmonary vasodilation
- Headache/flushing
- Profound hypotension with any NO donor
- Smooth muscle relaxation in corpus cavernosum and pulmonary vasculature
- Fatal hypotension with nitrates
- Headache, flushing, visual disturbance
Drugs with this mechanism (5)
- Tadalafil (PAH) — Long-acting tadalafil formulation for pulmonary arterial hypertension.
- Avanafil — Fast-onset PDE5 inhibitor for erectile dysfunction.
- Sildenafil — The first PDE5 inhibitor (Viagra); also treats pulmonary hypertension.
- Tadalafil — Long-acting PDE5 inhibitor for erectile dysfunction and BPH; never combine with nitrates.
- Vardenafil — PDE5 inhibitor for erectile dysfunction.
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