PDE3 inhibitor
Phosphodiesterase-3 inhibitor
- ↑ cAMP in myocardium and vascular smooth muscle
- Inotropy plus vasodilation — an “inodilator” for acute heart failure
- Excess cardiac stimulation → arrhythmia
- ↑ platelet cAMP → ↓ platelet aggregation
- Airway smooth-muscle relaxation → bronchodilation (inhaled)
- Inotropy plus vasodilation — the "inodilator" effect
Drugs with this mechanism (6)
- Aminophylline — Soluble theophylline; a bronchodilator with a narrow therapeutic index.
- Cilostazol — PDE3 inhibitor for intermittent claudication; contraindicated in heart failure.
- Dipyridamole — Antiplatelet vasodilator; used with aspirin and for cardiac stress testing.
- Ensifentrine — Inhaled dual PDE3/PDE4 inhibitor adding bronchodilation and anti-inflammatory activity in COPD.
- Milrinone — Inodilator that works through PDE3, so beta blockade does not block it.
- Theophylline — Old methylxanthine bronchodilator; narrow index, largely supplanted.
All mechanisms · Open PDE3 inhibitor in the interactive console ↗