PDE11 inhibitor
Phosphodiesterase-11 inhibitor
- Off-target inhibition of PDE11 in skeletal muscle and reproductive tissue
- The proposed basis of back pain and myalgia
- Off-target: expressed in skeletal muscle, prostate and testis, never the intended target
- Tadalafil is only 14-fold selective for PDE5 over PDE11A1, the narrowest gap of the class
- Proposed explanation for the back pain and myalgia that distinguish tadalafil from the other PDE5 inhibitors
Drugs with this mechanism (2)
- Tadalafil (PAH) — Long-acting tadalafil formulation for pulmonary arterial hypertension.
- Tadalafil — Long-acting PDE5 inhibitor for erectile dysfunction and BPH; never combine with nitrates.
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