P2Y12 antagonist
P2Y12 platelet receptor antagonist
- ↓ ADP-induced platelet activation/aggregation
- ↓ stent thrombosis and ischemic events after ACS
- Bleeding
- Blocks ADP-mediated platelet aggregation
Drugs with this mechanism (4)
- Clopidogrel active metabolite — Reactive thiol metabolite that irreversibly blocks platelet P2Y12 receptors; its formation depends partly on CYP2C19.
- Prasugrel — Potent P2Y12 antiplatelet; more effective but more bleeding than clopidogrel.
- Ticagrelor — Reversible P2Y12 antiplatelet; twice-daily, causes dyspnea.
- Ticlopidine — First-generation P2Y12 antiplatelet; neutropenia limited its use.
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