OX2 antagonist
Orexin-2 receptor antagonist
- Blocks the dominant wake-promoting orexin-2 (OX2) pathway → sleep
- Next-day somnolence, vivid dreams, sleep paralysis
- ↑ REM sleep
- ➔ possible cataplexy
- ➔ possible sleep paralysis
- ➔ possible abnormal dreams
- ➔ MDD
- ➔ agitation in dementia
Drugs with this mechanism (4)
- Daridorexant — Dual orexin antagonist hypnotic with a short half-life for less next-day effect.
- Lemborexant — Dual orexin antagonist hypnotic.
- Seltorexant — Investigational selective orexin-2 antagonist for insomnia and depression.
- Suvorexant — Dual orexin antagonist for sleep-onset and sleep-maintenance insomnia.
All mechanisms · Open OX2 antagonist in the interactive console ↗