NMDA receptor NAM
NMDA receptor negative allosteric modulator
- ↓ NMDA current without plugging the channel
- ➔ spermidine – ↑ autophagy, mitochondrial support, DNA/RNA stabilization ◇ supplements are used for longevity signaling
- ➔ spermine – strongest; major contributor to semen odor
- ➔ cadaverine – similar; produced during tissue decomposition
Drugs with this mechanism (1)
- Zinc — Essential trace mineral and NMDA modulator; OTC, used for colds and Wilson disease.
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