NHE3 inhibitor
NHE3 sodium-hydrogen exchanger inhibitor
- ↑ luminal sodium/water → softer stool
- ↓ intestinal phosphate absorption
- Blocks intestinal sodium absorption — increases stool water
- Also lowers phosphate absorption
Drugs with this mechanism (1)
- Tenapanor — NHE3 inhibitor for IBS-C and hyperphosphatemia; acts entirely in the gut lumen.
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