NCC inhibitor
Sodium-chloride cotransporter inhibitor
- Modest distal-tubule natriuresis with potassium and magnesium loss
- ↓ urinary calcium — useful in calcium stones and osteoporosis
- ↓ blood pressure
- Blocks sodium-chloride reabsorption in the distal tubule — the thiazides
- Hypokalemia, hyponatremia, hyperuricemia
- Reduces urinary calcium
Drugs with this mechanism (5)
- Chlorothiazide — The original thiazide diuretic; the only one available in an intravenous form.
- Chlorthalidone — Long-acting thiazide-like diuretic; preferred for hypertension outcomes.
- Hydrochlorothiazide — The most-prescribed thiazide diuretic for hypertension.
- Indapamide — Thiazide-like diuretic antihypertensive.
- Metolazone — Thiazide-like diuretic that works even in renal impairment; adds to loop diuretics.
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