NADPH: reductases
- Maintains antioxidant defense and drug metabolism
- G6PD deficiency starves this supply → oxidative hemolysis
- Glutathione reductase, thioredoxin reductase, CYP450 reductase — antioxidant defense and drug metabolism draw on the same NADPH pool
- G6PD deficiency = an NADPH supply problem presenting as oxidative hemolysis
Drugs with this mechanism (1)
- NADP — Phosphorylated NAD coenzyme; its reduced form, NADPH, supports biosynthesis and antioxidant defenses.
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