Mucosal barrier
Ulcer-adherent mucosal barrier
- Shields ulcers from acid and pepsin
- Nonselective binding can trap other luminal drugs — separate dosing
- Forms an adherent barrier over ulcerated mucosa
- Binding is non-selective — other drugs are bound too
Drugs with this mechanism (2)
- Bismuth subsalicylate — OTC mucosal protectant and antidiarrheal; salicylate toxicity and interactions still apply.
- Sucralfate — Sucrose-aluminum complex that polymerizes on ulcer craters; binds other drugs.
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