Microtubule stabilizer
- Prevents microtubule disassembly → freezes cells in mitosis
- Cytotoxicity in solid tumors
- Disrupted axonal transport → peripheral neuropathy
- Freezes microtubules, arresting mitosis
- Peripheral neuropathy and neutropenia
- Hypersensitivity to the solubilizing vehicle
Drugs with this mechanism (1)
- Paclitaxel — Taxane chemotherapy that stabilizes microtubules; neuropathy often limits treatment.
All mechanisms · Open Microtubule stabilizer in the interactive console ↗