LPS membrane disruptor
Bacterial LPS membrane disruptor
- Membrane leakage → bacterial death
- A last-resort agent for resistant Gram-negatives
- Nephro- and neurotoxicity
- Disrupts the bacterial outer membrane — the polymyxins
- Nephrotoxicity and neurotoxicity
Drugs with this mechanism (1)
- Polymyxin B — Cationic detergent antibiotic that disrupts gram-negative outer membranes.
All mechanisms · Open LPS membrane disruptor in the interactive console ↗