MC4R agonist
Melanocortin-4 receptor agonist
- ↓ appetite and ↑ satiety → treats monogenic obesity syndromes
- ↑ sexual desire and arousal
- Reduces appetite in genetic obesity syndromes
- Skin hyperpigmentation
Drugs with this mechanism (3)
- α-MSH — POMC-derived peptide: pigment at MC1R, appetite and energy at MC3R/MC4R.
- Bremelanotide — On-demand melanocortin-4 agonist injection for premenopausal hypoactive sexual desire disorder.
- Setmelanotide — MC4R agonist for genetic obesity syndromes.
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